| Autor: |
Wathelet, Marc G., Szpirer, Josiane, Nols, Christine B., Clauss, Isabelle M., De Wit, Lukas, Islam, M. Quamrul, Levan, Göran, Horisberger, Michel A., Content, Jean, Szpirer, Claude, Huez, Georges A. |
| Zdroj: |
Somatic Cell and Molecular Genetics; September 1988, Vol. 14 Issue: 5 p415-426, 12p |
| Abstrakt: |
When cells are treated with interferon several new proteins are induced. We have isolated by differential screening two cDNA clones corresponding to human genes inducible by IFN-a, termed IFI-4 and IFI-54K. The accumulation of the corresponding mRNA was followed as a function of either IFN dose or of time. The IFI-4 and IFI-54K genes, as well as two previously isolated IFN-inducible genes, namely the IFI-56K and low-molecular-weight 2–5A synthetase, were localized on the human chromosomes. Using cloned probes on Southern blots of DNA from a panel of rodent-human somatic cell hybrids, we have assigned the IFI-4 gene to chromosome 1 and the gene coding for the low-molecular-weight 2–5A synthetase to chromosome 12. We also showed that the IFI-54K and IFI-56K genes, unlike most of the IFN-inducible genes, are syntenic. They are both located on chromosome 10. In addition, evidence is given for the presence of a pseudogene homologous to IFI-56K on chromosome 13. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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