Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

Autor: Honey, N. K., Sakaguchi, A. Y., Lalley, P. A., Quinto, C., MacDonald, R. J., Craik, C., Bell, G. I., Rutter, W. J., Naylor, S. L.
Zdroj: Somatic Cell and Molecular Genetics; July 1984, Vol. 10 Issue: 4 p377-383, 7p
Abstrakt: The mouse genes for the serine proteases trypsin (Try-1,chymotrypsin B (Ctrb),and elastase (Ela-1)were chromosomally assigned using Southern blot hybridization of mouse × Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb,and Ela-1was correlated with the segregation of mouse chromosomes. Try-1is located on chromosome 6, Ctrbis on chromosome 8, and Ela-1is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.
Databáze: Supplemental Index