| Autor: |
Ugwu, Sydney O., Alcala, Marcos J., Bhardwaj, Rend, Blanchard, James |
| Zdroj: |
Journal of Inclusion Phenomena and Macrocyclic Chemistry; March 1996, Vol. 25 Issue: 1-3 p173-176, 4p |
| Abstrakt: |
The equilibrium dialysis method was applied to the determination of drug-cyclodextrin stability constants using diflunisal and 2-hydroxypropyl-ß-cyclodextrin (HPBCD) as a model system. Analysis of data showed the existence of a linear Scatchard plot, which is indicative of the formation of a 1:1 dlflunisal:LIPBCD complex. The stoichiometry of the complex was verified using the appropriate mass action law equation. The complexation constant (Kc) was 3801 ± 541 M-1. The Kc obtained using the equilibrium dialysis method was comparable to that obtained using a potentiometric method (5564 ± 56 M-1). |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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