Automatic control of anesthesia using two feedback variables

Autor: Schils, George F., Sasse, Frank J., Rideout, Vincent C.
Zdroj: Annals of Biomedical Engineering; January 1987, Vol. 15 Issue: 1 p19-34, 16p
Abstrakt: A new controller of anON/OFFtype was implemented for halothane anesthesia. A proportional-plus-integral controller with time-delay compensation proved not to be robust enough for the known clinical situation, as shown both in computer simulations and in animal trials. TheON/OFFcontroller proved to be less sensitive to parameter mismatches, and repeated animal trials showed a short response time and acceptable steady-state tracking. A method for switching the controlled effect of the drug was also developed, since anesthetic agents have multiple effects. Mean arterial blood pressure and a measure ofEEGfrequency were chosen as controlled variables, both being depressed by halothane. A coordinator forces the system state as near the desired values of these variables as possible, given that only one drug is used.
Databáze: Supplemental Index