| Autor: |
Ole-Mapenay, I. M., Mitema, E. S. |
| Zdroj: |
Veterinary Research Communications; September 1995, Vol. 19 Issue: 5 p425-432, 8p |
| Abstrakt: |
A compartmental and non-compartmental study was carried out on five adult goats following intramuscular administration of doxycycline at 20 mg/kg bodyweight. The concentration of the drug in serum was determined by a microbiological assay employingBacillus cereus varmycoides (ATCC 11778) as the test organism. The mean serum concentration (Cmax) and the time of maximum concentration (Tmax) were 1.87 µg/ml and 0.85 h, respectively. Using compartmental analysis, the plasma concentration-time curve of doxycycline best fitted a three-compartment open model with first-order absorption. A three-phase disposition of doxycycline was found, the terminal elimination half-life being approximately 40 h. |
| Databáze: |
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| Externí odkaz: |
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