Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial

Autor: Guthkelch, A. N., Carter, L. P., Cassady, J. R., Hynynen, K. H., Iacono, R. P., Johnson, P. C., Obbens, E. A. M. T., Roemer, R. B., Seeger, J. F., Shimm, D. S., Steal, B.
Zdroj: Journal of Neuro-Oncology; June 1991, Vol. 10 Issue: 3 p271-284, 14p
Abstrakt: Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5°C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42°C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.
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