| Autor: |
Fleig, H., Patil, P., Krieglstein, G. |
| Zdroj: |
International Ophthalmology; February 1987, Vol. 10 Issue: 1 p15-22, 8p |
| Abstrakt: |
The disposition of 3H-(-)-noradrenaline (NA) was studied in the iris isolated from albino and pigmented rabbits.1.Pigment cells bind some NA, but do not metabolize it.2.Cocaine-sensitive neuronal uptake leads either to an extensive neuronal deamination of NA (when vesicular uptake is inhibited by pretreatment of the animals with reserpine) or to a pronounced accumulation of NA in the axoplasm (if, additionally, neuronal monoamine oxidase is inhibited).3.Corticosterone-sensitive extraneuronal uptake leads to O-methylation of NA by extraneuronal catechol-O-methyl-transferase. In the rabbit iris, there is no extra-neuronal deamination of NA. In contrast to findings with other tissues, the extraneuronal O-methylation of NA in the rabbit iris is not saturable. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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