Redistribution of histones during unfolding of chromosomal DNA

Autor: Varshavsky, Alexander J., Georgiev, Georgii P.
Zdroj: Molecular Biology Reports; October 1973, Vol. 1 Issue: 3 p143-148, 6p
Abstrakt: Just in the course of unfolding of chromosomal deoxyribonucleoproteins performed in the absence of magnesium ions all DNA-bound histones may be redistributed. This type of redistribution is completely blocked in already ‘unfolded’ DNP preparations. If the unfolding-induced histone redistribution is allowed it leads to a significant decrease of the average length of free DNA segments in the unfolded, histone F1-depleted DNP. The implications of these data on the mode of DNA packing in chromatin are discussed.
Databáze: Supplemental Index