| Autor: |
Hinsvark, Orville, Truant, Aldo, Jenden, Donald, Steinborn, Joseph |
| Zdroj: |
Journal of Pharmacokinetics and Pharmacodynamics; August 1973, Vol. 1 Issue: 4 p319-328, 10p |
| Abstrakt: |
Plasma levels of amphetamine and phentermine have been measured in man in a crossover study of the pharmacokinetics of these agents following oral administration of resin-bound and soluble salt formulations. The one-compartment open model with first-order drug absorption was fitted to the data from each subject by nonlinear regression methods and provided an excellent fit. Relative bioavailability of the two salts did not differ for either drug. In both cases the rate constant for absorption was significantly lower and less variable for the resinated compound. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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