| Autor: |
Igarashi, Muneo, Hosoda, Nozomi, Bando, Yuki, Shimanuki, Kaoru, Sunaoshi, Wataru, Shirai, Hiroyuki, Miura, Hisao |
| Zdroj: |
Journal of Clinical Immunology; September 1992, Vol. 12 Issue: 5 p335-340, 6p |
| Abstrakt: |
An anticarbamazepine antibody was detected in the serum of a patient with severe carbamazepine-induced serum sickness. We found that the patient's T cells and IgG antibody recognized an epitope which appeared in subjects showing an allergic reaction, as well as that in subjects who showed no allergic reaction, after long-term carbamazepine therapy. These results show that an anti-carbamazepine immune response does not occur in the majority of subjects who undergo long-term carbamazepine therapy without developing allergic symptoms, although the immunodominant haptenic epitope of carbamazepine is present in their sera. |
| Databáze: |
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| Externí odkaz: |
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