| Autor: |
Indzhiia, Leonora V., Yakovleva, Lelita A., Overbaugh, Julie, Licciardi, Karen A., Chikobava, Mirabi G., Klotz, Igor N., Torres, Raul, Indzhiia, Victoria O., Lapin, Boris A., Clark, Edward A., Valentine, Mary A. |
| Zdroj: |
Journal of Clinical Immunology; May 1992, Vol. 12 Issue: 3 p225-236, 12p |
| Abstrakt: |
Papio hamadryas baboons in the Sukhumi colony develop enzootic outbreaks of malignant lymphomas with an incidence of about 1.5% per year among adults of the high-risk stock. We investigated the surface phenotypes of cells from normal and lymphomatous animals using antibodies against human lymphocyte antigens. We found that more than 80% of the lymphomas that developed during the last 3 years were characterized histologically to be of the peripheral T cell type. Generally, the lymphomatous cells also expressed high levels of MHC class II DR protein, CD18 (LFA-1 beta chain), and CD45RO. Surprisingly, these cells also expressed on their surface two proteins previously characterized as being relatively B cell-restricted: CD40 and Bgp95. These proteins were never found on the peripheral blood T cells from normal animals. The expression of these two gene products was confirmed by RNA blotting and immunoprecipitation. In most cases, the two B cell-associated proteins were expressed on the predominant T cell subsets; we found both B cell proteins on CD4+, CD8+ as well as on the CD4/8 double-positive cells when these subsets were expressed at high levels. About 90% of these animals are seropositive forHerpesvirus papio and human T cell leukemia virus-1 (HTLV-1) before developing outright lymphomas. In all of the lymphoma samples, HTLV-1 tax DNA sequences were detected by PCR amplification. Whether or not HTLV-1 or theHerpesvirus papio gene products influence the surface expression of CD40 and Bgp95 remains to be determined. |
| Databáze: |
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