Clinical significance of IgG subclasses of anti-Sm and U1 ribonucleoprotein antibodies in patients with systemic lupus erythematosus and mixed connective tissue disease

Autor: Tokano, Yoshiaki, Yasuma, Mitsuhiko, Harada, Shigenori, Takasaki, Yoshinari, Hashimoto, Hiroshi, Okumura, Ko, Hirose, Shunichi
Zdroj: Journal of Clinical Immunology; November 1991, Vol. 11 Issue: 6 p317-325, 9p
Abstrakt: IgG subclasses of anti-Sm and anti-U1 ribonucleoprotein (U1 RNP) antibodies were determined using a new clone of the anti-IgG2 antibody (HG2-56F). Although the predominance of IgG1 coincided with previous reports, IgG2 anti-Sm and U1 RNP antibodies were detected in numerous patients. IgG3 anti-Sm antibody significantly correlates with joint involvement and a high titer of anti-DNA antibody. On the other hand, IgG4 anti-U1 RNP antibody significantly correlated with esophageal dilation and muscular involvement. These results may suggest that some IgG subclasses are related to a specific clinical feature or manifestation.
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