Hereditary abnormalities of the OKT4 human lymphocyte epitope in two families

Autor: Karol, Robin A., Eng, Jerald, Dennison, David K., Faris, Elizabeth, Marcus, Donald M.
Zdroj: Journal of Clinical Immunology; January 1984, Vol. 4 Issue: 1 p71-74, 4p
Abstrakt: The lymphocytes of two unrelated black individuals exhibited no immunofluorescent staining by a monoclonal antibody, OKT4, that reacts with T helper/inducer cells, but the lymphocytes reacted normally with four other monoclonal antibodies that identify T helper cells. Four first-degree relatives of these individuals were available for study. They had a normal proportion of OKT4+ lymphocytes but these cells had approximately half the normal number of OKT4 sites. This abnormality appears to be inherited as an autosomal recessive state.
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