| Autor: |
Warr, S R C, Gershater, C J L, Box, S J |
| Zdroj: |
Journal of Industrial Microbiology and Biotechnology; May 1996, Vol. 16 Issue: 5 p295-300, 6p |
| Abstrakt: |
Fermentation development for improved culture productivity can be achieved in a number of ways. Conventional approaches usually concentrate initially on optimisation of the final stage fermentation. However an understanding of the seed stage and its further development can lead to an improvement in final stage productivity. A significant increase in the production of milbemycin VM44866 byStreptomyces hygroscopicus was achieved by manipulation of several factors associated with the seed stage fermentation. Juvenile seeds and seed media containing reduced levels of carbohydrates overcame the detrimental effects of passaging and seed age associated with the standard (control) process. The effect of final stage inoculum level was seed medium-dependent and seed fermentation incubation temperature also affected subsequent milbemycin VM44866 production. These findings were extended to a second milbemycin-producing strain and these results have demonstrated the potential benefits of seed stage optimisation for improved final stage production. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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