Alteration of some toxic aflatoxin responses in Syrian hamsters fed zinc carbonate-supplemented diets

Autor: Llewellyn, G. C., Hoke, G. D., O'Rear, C. E., Mayfield, J. E., Dashek, W. V.
Zdroj: Journal of Industrial Microbiology and Biotechnology; March 1986, Vol. 1 Issue: 1 p1-8, 8p
Abstrakt: Summary Chronic exposure to aflatoxins (AFTs) below the LD50 can result in reduced weight gain, hepatocellular necrosis and bile duct cell proliferation. Here, we report whether dietary zinc (Zn2+) protects against both aflatoxicosis and precancer in male weanling hamsters fed either 14.6 mg/kg AFTs, 3000 mg/kg zinc carbonate, or both for 17 weeks. The AFTs (either alone or with Zn2+) reduced weight gains but not feed consumption. Whereas controls possessed 172.7±21.7 mg/100 ml plasma glucose, the AFTs and Zn2+ groups had 132.1±19.5 and 122.7 mg/100 ml, respectively. For plasma cholesterol, the AFTs plus Zn2+ group's was 26.5±4.3 compared to 32.3±3.0, 31.5±4.8 and 36.0±2.1 mg/100 ml for control, Zn2+ and AFTs groups, respectively. The latter exhibited bile duct cell hyperplasia, focal liver necrosis and hemorrhage but the AFTs plus Zn2+ group's livers had less damage. Meglahepatocytes indicated precancerous changes. These data suggest a trend toward Zn2+-induced reduction for AFTs-promoted liver damage.
Databáze: Supplemental Index
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