| Autor: |
Nowak-Göttl, U., Boos, J., Wolff, J., Lill, H., Veltmann, H., Werber, G., Ahlke, E., Jürgens, H. |
| Zdroj: |
International Journal of Clinical & Laboratory Research; September 1995, Vol. 25 Issue: 3 p146-148, 3p |
| Abstrakt: |
Summary: l-Asparaginase treatment of leukemia patients causes hemostatic problems. To investigate whetherl-asparaginase influences coagulation studies, 63 blood samples of 21 healthy male donors were incubated withl-asparaginase for 30 min at room temperature. After treatment with 100 IU/mll-asparaginase plasma fibrinogen (P=0.002), plasma antithrombin (P=0.0002), plasma protein C (P=0.0004), and plasma plasminogen (P=0.0039) were decreased compared with controls. In contrast, a significant increase in plasma von Willebrand factor antigen (P=0.08) and plasma thromboglobulin (P=0.005) was observed. The decrease in plasma antithrombin (P=0.001), plasma protein C (P=0.0003), and plasma plasminogen (P=0.0043) was also measurable after 0.05 IU/ml asparaginase treatment. The incubation withl-asparaginase was similar to the normal time from blood sampling to testing and hence the results suggest thatl-asparaginase may directly attack proteins of the coagulation system during the interval between sampling and assay. |
| Databáze: |
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