| Autor: |
Castoldi, Gianluigi, Borsetti, Gabriella, Abbasciano, Vincenzo, Scapoli, Gianluigi |
| Zdroj: |
International Journal of Clinical & Laboratory Research; July 1979, Vol. 9 Issue: 3 p265-271, 7p |
| Abstrakt: |
Nucleolar persistence in metaphase plates is a feature observed in most of the cells in neoplastic processes. Pathological persistence or fragmentation of the nucleoli is thought to be the cause of some numerical chromosomal aberrations due to non-disjunction of the chromatids, with particular involvement of the satellite chromosomes. Thus, a combined selective staining of both the nucleoli (amido black 10B according to Mundkur and Brauer's cytochemical technique) and the chromosomes (neutral red) was applied to the metaphase plates of patients with chronic myeloid leukaemia in the blastic crisis. Duplicated Ph1was associated with amido black-stained areas at a very high rate in some cases. Since the blastic crisis in chronic myeloid leukaemia is |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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