| Autor: |
Frayssinet, P., Primout, I., Rouquet, N., Autefage, A., Guilhem, A., Bonnevialle, P. |
| Zdroj: |
Journal of Materials Science: Materials in Medicine; October 1991, Vol. 2 Issue: 4 p217-221, 5p |
| Abstrakt: |
Cancellous bone cells were isolated from adult dogs, introduced into cell culture, subcultured and grown on hydroxylapatite granules. Cells immobilized on these granules were used to make bioreactors which were implanted in dog ulna diaphyse to fill osseous defects. The bioreactor implantation constituted a bone cell autograft and showed bone formation in a reactor containing cultured cells but not in the control reactor containing hydroxylapatite granules without cells. These results indicate that hydroxylapatite material can be used in bioartificial organs. The properties of hydroxylapatite used in bone reconstruction are due to the cells and extra-cellular matrix immobilized on its surface. |
| Databáze: |
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| Externí odkaz: |
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