| Autor: |
Grups, J. W., Schmitz-Dräger, B. J., Ebert, T., Ackermann, R. |
| Zdroj: |
World Journal of Urology; December 1986, Vol. 3 Issue: 4 p224-229, 6p |
| Abstrakt: |
Interferons (IFN) are a class of glycoproteins which have antiviral, antiproliferative and immunomodulating properties. Three major classes of IFN are characterized today on the basis of antigenic and physical-chemical properties. They modulate various immunological functions and can be characterized as biological response modifiers. In addition, they have direct cytotoxic effects on tumor cells. Since 1978, interferons have been in clinical use as antineoplastic agents in patients with superficial bladder tumors. The first reports on the treatment of superficial bladder tumors with natural IFN preparations offered encouraging results. Recently published data with systemically applied recombinant IFN alpha-2, however, did not confirm the good results previously reported. One of the reasons for these conflicting results might be the different types of IFN alpha used. Since laboratory results have demonstrated that reduction of the tumor cell multiplication rate can be influenced by the concentration of IFN, topical application, e.g. in the therapy of superficial bladder carcinoma, may offer more promising results in comparison to systemic application. Further knowledge on the immunomodulatory and anticellular mechanisms is needed in order to allow a successful application of IFN in the treatment of cancer. |
| Databáze: |
Supplemental Index |
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