Autor: |
Kaufmann, S. H. E., Flesch, I. E. A., Munk, M. E., Wand-Württenberger, A., Schoel, B., Koga, T. |
Zdroj: |
Rheumatology International; November 1989, Vol. 9 Issue: 3-5 p181-186, 6p |
Abstrakt: |
Mycobacteria are intracellular pathogens capable of replicating in resting macrophages. Specific helper T lymphocytes which activate antimycobacterial capacities in infected macrophages represent an important constituent of acquired resistance. In addition, cytolytic T lymphocytes may contribute to resistance. On the other hand, lysis of infected host cells may also comprise autoaggressive consequences. Recent evidence suggest that T cells with specificity for mycobacterial heat shock proteins are involved in the antimycobacterial immune response. Heat shock proteins are evolutionarily highly conserved and cross-reactivity between microbial and mammalian molecules may occur on the B-cell and T-cell level. Thus, T cells directed against shared epitopes of mycobacterial and autologous origin could initiate autoimmune reactions. |
Databáze: |
Supplemental Index |
Externí odkaz: |
|