Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: Cross-talk of calcium, protein kinase C (PKC), and arachidonic acid

Autor: Naor, Zvi, Shacham, Sharon, Harris, Dagan, Seger, Rony, Reiss, Nachum
Zdroj: Cellular and Molecular Neurobiology; October 1995, Vol. 15 Issue: 5 p527-544, 18p
Abstrakt: Summary 1. The decapeptide neurohormone gonadotropin releasing hormone (GnRH) is the first key hormone of the reproductive system. Produced in the hypothalamus, GnRH is released in a pulsatile manner into the hypophysial portal system to reach the anterior pituitary and stimulates the release and synthesis of the gonadotropin hormones LH and FSH. GnRH, a Ca2+ mobilizing ligand, binds to its respective binding protein, which is a member of the seven transmembrane domain receptor family and activates a G-protein (Gq).
Databáze: Supplemental Index