| Autor: |
Slater, N. T., Carpenter, D. O. |
| Zdroj: |
Cellular and Molecular Neurobiology; March 1982, Vol. 2 Issue: 1 p53-58, 6p |
| Abstrakt: |
1.The effects of strychnine and desipramine on excitatory responses to acetylcholine (ACh) were compared with those of hexamethonium and atropine over a range of membrane potentials in voltage clampedAplysia neurons.2.All these compounds reduced the steady-state ACh-induced current at the membrane potentials studied (-60 to -120 mV).3.The blockade produced by hexamethonium and atropine was markedly voltage dependent, the degree of antagonism increasing with hyperpolarization.4.In contrast, the antagonistic effects of strychnine and desipramine displayed no voltage dependency.5.Unlike the presumed channel blocking drugs hexamethonium and atropine, strychnine and desipramine appear to act either at the receptor or at some other site not influenced by membrane potential. |
| Databáze: |
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| Externí odkaz: |
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