| Autor: |
Wiegant, Fred A. C., Souren, Jan E. M., Rijn, Han, Wijk, Roeland |
| Zdroj: |
Cell Biology and Toxicology; January 1993, Vol. 9 Issue: 1 p49-59, 11p |
| Abstrakt: |
Our data show that a short incubation with arsenite (30–300 µM) induces a biphasic change in ceSlular sensitivity towards a second exposure to arsenite. A transient sensitization was followed by the development of self-tolerance. Sensitization was measured using the step-down protocol; i.e., application of a high dose of arsenite pretreatment (100 or 300 µM) followed immediately by incubation in a low dose of arsenite (1–30 µM), with extensive rinsing in between. Whereas no effect of 1 and 3 µM on cellular survival is observed without pretreatment, a large decrease in cell survival can be established when these low doses of arsenite are applied immediately after a 1 hr pretreatment with 100 or 300 arsenite. |
| Databáze: |
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