Pulmonary blood flow profiles with reduced right ventricular function in lambs

Autor: Katayama, Hiroshi, Henry, G. William, Krzeski, Robert, Lucas, Carol L., Ha, Belinda, Ferreiro, Jose I.
Zdroj: Heart and Vessels; March 1996, Vol. 11 Issue: 2 p57-63, 7p
Abstrakt: Summary The determinants of right ventricular (RV) performance with damaged RV free wall, such as occurs with RV infarction, are still unclear. Using 20-MHz Doppler ultrasound equipment, we investigated the changes in pulmonary blood flow velocity profiles before and after ligation of the right coronary artery. RV dp/dt, stroke volume, RV stroke work, aortic pressure and cardiac output decreased and central venous pressure rose after the ligation. The RV stroke work — enddiastolic pressure relationship indicated impaired RV function following ligation. We observed shortened acceleration time (65.0 ± 15.1 vs 54.4 ± 6.2ms,P < 0.05) and reduced maximum velocity of forward flow (59.0 ± 5.9 vs 52.5 ± 7.6cm/s,P < 0.05) after the ligation. Acceleration was interrupted earlier after ligation than before ligation. These alterations in flow are thought to be a consequence of the altered movement of the RV free wall and ventricular septum induced by RV infarction.
Databáze: Supplemental Index