| Autor: |
Akiba, Takashi, Ando, Ryoiti, Shioyama, Ken-ichi, Kuriyama, Renjiro, Chida, Yoshiko, Ono, Jyugoro, Kurihara, Satoshi, Hoshino, Masanobu, Togashi, Kazuyoshi, Marumo, Fumiaki |
| Zdroj: |
Journal of Bone and Mineral Metabolism; December 1991, Vol. 9 Issue: 3 p49-55, 7p |
| Abstrakt: |
Abstract: We attempted to confirm whether intermittent high-dose oral 1,25-dihydroxyvitamin D3 (PULSE) suppressed parathyroid hormone (PTH) secretion, inhibited parathyroid cell proliferation, and increased bone mass in uremic patients (Pts). Twenty two long-term hemodialysis Pts with secondary hyperparathyroidism were given 3.40.8g 1,25 dihydroxyvitamin D3 twice a week for 9.53.3 M. The size of parathyroid gland (PT) was estimated by echography and computed tomography every 3 months. Bone mineral density of the radius (BAD) was measured by single photon absorptiometer (Norland SPA 26). Findings were:- | Before PULSE | 6 months | P-value | Ca (mg/dl) | 9.96 1.18 | 11.15 1.61 | <0.001 | P (mg/dl) | 5.17 1.83 | 5.78 1.11 | n.s. | Alk-Pase (IU) | 373 385 | 167 79 | <0.005 | HS-PTH (ng/ml) | 49.931.5 | 8.013.83 | <0.005 | I-PTH (pg/ml) | 563 453 | 165 101 | <0.005 |
The volumes of 22 PT detected by echography in 11 Pts before and after PULSE were 363385 and 434462cmm (n.s.), respectively. In 6 Pts before the PULSE therapy began and after 11.OM of PULSE, The BAD values were measured in 6 Pts before and after 11.OM of PULSE. They were 0.3880.115 and 0.3980.093 g/cm2 (n.s.), respectively. We conclude that at this dose schedule, PULSE suppresses PTH secretion, but does not decrease PT size or increase the bone mass. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink