| Autor: |
Panayotides, Panos, Lenkei, Rodica, Porwit, Anna, Reizenstein, Peter |
| Zdroj: |
Medical Oncology; September 1986, Vol. 3 Issue: 3-4 p255-263, 9p |
| Abstrakt: |
Interleukin-2 (IL-2) for a long time has been considered as a T-cell specific growth factor which acts through distinct surface receptors present on activated, but not on resting, T-lymphocytes. Recently it has been shown that activated murine and human B-cells also express IL-2 receptors and respond to IL-2 with an increase of DNA synthesis. Some human B-cell malignancies have been reported to react with anti-IL-2 receptor antibodies, but no response to IL-2 has been documented in these cases. Here, in five of 11 B-cell leukemia/lymphoma cases, we identified cells which not only express the IL-2 receptor, but also respond to IL-2 stimulation, as shown by a marked increase of3H-thymidine incorporation and by differentiation of lymphoma cells. The IL-2-induced3H-thymidine uptake was completely blocked by a monoclonal antibody to IL-2 receptor, which indicates that IL-2 acted directly through functional IL-2 receptors. |
| Databáze: |
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