| Autor: |
Yuxian, Chen, Hanzhang, Xia, Xiaoying, Zhang, Yanfen, Li, Feng, Chen, Wei, Shi, Bingze, Xu, Yirong, Huang, Youhui, Zhang |
| Zdroj: |
Chinese Journal of Cancer Research; June 1990, Vol. 2 Issue: 2 p28-30, 3p |
| Abstrakt: |
Abstract: This paper described T cell proliferative response by an alternative pathway in normal subjects and in patients with malignant diseases. Two McAbs, Anti-CCT1 and Lo-CD2-act recognizing two distinct epitopes on E-receptor (CD2) were used to costimulate PBMC. Proliferative responsiveness was measured by3H-thymidine incorporation. It was found that 82% of 72 normal subjects gave proliferative response whereas only 23% of the 93 patients did. The average cpm±SD in patients with bladder cancer (118±2314), kidney cancer (1619±2719) or lymphoma (2518±4057) was significantly lower than that in normal subjects (4935±2314), (P<0.001). These results indicate that T cell proliferation through the alternative pathway was significantly depressed in patients with cancer, and this can be used as a new parameter to monitor the immune status of cancer patients. |
| Databáze: |
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