| Autor: |
Zhenfu, Fan, Zhizhou, Chen, Peizhong, Lin, Jinsheng, Zhang, Changyou, Liu, Ping, Su |
| Zdroj: |
Chinese Journal of Cancer Research; September 1989, Vol. 1 Issue: 4 p47-49, 3p |
| Abstrakt: |
Abstract: Serum spermidine was assayed by radioimmunoassay in different stages of esophageal carcinogenesis in the population from high risk area of esophageal cancer, Linxian County. The serum spermidine values were 76.94�74.38 ng/ml in 36 normal individuals; 115.71�113.45 ng/ml in 35 patients with marked epithelial hyperplasia (MEH) and 294.48�135.36 ng/ml in 31 patients with early esophageal cancer. Patients with MEH were given intervention treatment by Aminoretinoic Ester or Anticancer B or placebo (starch) as controls. One year later, samples from the population were collected again for serum spermidine measurement. The values were 95.8+68.2 ng/ml in 27 normals; 125.1�72.9 ng/ml in 62 patients with MEH treated by Anticancer B; 125.6�117.2 ng/ml in 64 patients with MEH treated by Aminoretinoic Ester; 162.4�76.6 ng/ml in 62 controls and 210.5�182.9 ng/ml in 44 patients with early esophageal cancer. The results showed that spermidine radioimmunoassay could reflect the tendency of esophageal precancerous changes toward cancer or back to nromal. They can be taken as a mid-way monitor indicator for tumor-blocking drugs. Also, it could be of value in the early diagnosis of esophageal cancer. |
| Databáze: |
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