| Autor: |
Tsotinis, Andrew, Vlachou, Marilena, Gerasimopoulou, Maria, Eikosipentaki, Aphrodite, Ioannidis, Constantine, Klouvidaki, Anna, Afroudakis, Pandelis A., Moreau, Dimitri, Roussakis, Christos |
| Zdroj: |
Letters in Drug Design & Discovery; March 2007, Vol. 4 Issue: 2 p87-91, 5p |
| Abstrakt: |
The synthesis, pharmacological properties and delivery characteristics in simulated aqueous gastric fluid of a series of symmetrical nitrogenated C2-substituted pyrrolo[2,3-f]quinolines are described. The cytotoxicity of the target molecules (5a-h) was evaluated in the human non-small lung cancer cell line NSCLCN16- L16 in vitro. One compound (5e) showed sufficient activity (IC50 = 26.4 μM) and satisfactory release characteristics from solid pharmaceutical formulations. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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