Catalytic, Asymmetric Synthesis of Cyanohydrin Esters: The Effect of Anhydride Structure on Enantioselectivity

Autor: Belokon, Y. N., Carta, P., North, M.
Zdroj: Letters in Organic Chemistry; January 01, 2004, Vol. 1 Issue: 1 p81-83, 3p
Abstrakt: A bimetallic titanium(salen) complex has been shown to catalyse the asymmetric addition of potassium cyanide to aldehydes in the presence of a range of anhydrides, leading to cyanohydrin esters. Linear aliphatic anhydrides (acetic and propionic) gave products with higher enantiomeric purity than those obtained using pivalic or benzoic anhydrides.
Databáze: Supplemental Index