| Autor: |
Perez-Caro, Maria, Perez-Mancera, Pedro A., Voces, Felipe, Sanchez-Garcia, Isidro |
| Zdroj: |
Current Genomics; March 2005, Vol. 6 Issue: 2 p81-88, 8p |
| Abstrakt: |
To date, many genetic changes have been described and reported in the cancer process. Since the first mutations were described, several attempts to establish genotype-phenotype correlations for these genetic alterations have been reported. Moreover, in vitro data have suggested effects of mutant proteins in proliferation. Genotype-phenotype correlations are not only important for predicting the clinical course of the disease and to allow tailor-made surveillance of individuals at risk, but also have implications for the elucidation of the molecular genetic mechanisms underlying genesis of cancer and the development of gene-based therapies. Here, we discuss genotype-phenotype correlation of cancer in mouse and man, and the functional aspects that may account for these observations important to both understand and treat the human disease process. |
| Databáze: |
Supplemental Index |
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