Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorderHow to cite this article: GarcíaNonell C, Ratera ER, Harris S, Hessl D, Ono MY, Tartaglia N, Marvin E, Tassone F, Hagerman RJ. 2008. Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorder. Am J Med Genet Part A 146A:1911–1916.

Autor: GarcíaNonell, Catalina, Ratera, Eugenia Rigau, Harris, Susan, Hessl, David, Ono, Michele Y., Tartaglia, Nicole, Marvin, Emily, Tassone, Flora, Hagerman, Randi J.
Zdroj: American Journal of Medical Genetics. Part A; August 2008, Vol. 146 Issue: 15 p1911-1916, 6p
Abstrakt: This study examined whether secondary medical diagnoses that affect CNS function i.e., seizures, malformations, or genetic disorders, are more likely to occur in individuals with fragile X syndrome FXS and autism spectrum disorder FXS  ASD or FXS alone. Ninety males 3–25 years with FXS or FXS  ASD were evaluated for secondary medical diagnoses by medical history and examination. A significant difference in the incidence of medical problems was found between patients with FXS  ASD 38.6 and FXS alone 18.2, P < 0.05. Medical problems that affect the CNS are more likely to occur in those with FXS  ASD and it is probable that additional brain dysfunction associated with these medical problems enhance the risk of autism in those with FXS. © 2008 WileyLiss, Inc.
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