| Autor: |
L. Whitson, Emily, S. Bugni, Tim, S. Chockalingam, Priya, P. Concepcion, Gisela, Kay Harper, Mary, He, Min, N. A. Hooper, John, C. Mangalindan, Gina, Ritacco, Frank, M. Ireland, Chris |
| Zdroj: |
Journal of Natural Products; June 2008, Vol. 71 Issue: 7 p1213-1217, 5p |
| Abstrakt: |
Three new sterol sulfates, spheciosterol sulfates A−C ( 1− 3), and the known sterol sulfate topsentiasterol sulfate E ( 4) have been isolated from the sponge Spheciospongiasp., collected in the Philippines. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1− 4inhibited PKCζ with IC 50values of 1.59, 0.53, 0.11, and 1.21 μM, respectively. In a cell-based assay, 1− 4also inhibited NF-κB activation with EC 50values of 12−64 μM. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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