| Autor: |
S. Donia, Marwa, Wang, Bin, C. Dunbar, Daniel, V. Desai, Prashant, Patny, Akshay, Avery, Mitchell, T. Hamann, Mark |
| Zdroj: |
Journal of Natural Products; May 2008, Vol. 71 Issue: 6 p941-945, 5p |
| Abstrakt: |
Two new cyclic hexapeptides, mollamides B ( 1) and C ( 2), were isolated from the Indonesian tunicate Didemnum mollealong with the known peptide keenamide A ( 3). The structures were established using 1D and 2D NMR experiments. The relative configuration of mollamide B at the thiazoline moiety was determined using molecular modeling coupled with NMR-derived restraints. Their absolute configuration was determined using Marfeyʼs method. The new peptides have been evaluated for their antimicrobial, antimalarial, anticancer, anti-HIV-1, anti-Mtb, and anti-inflammatory activities. Keenamide A and mollamide B show cytotoxicity against several cancer cell lines. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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