| Autor: |
Malek-Ahmadi, Parviz, Ghandour, Elias |
| Zdroj: |
The Annals of Pharmacotherapy; July 2004, Vol. 38 Issue: 7-8 p1202-1205, 4p |
| Abstrakt: |
OBJECTIVE: To report the effect of bupropion in a patient with interferon (IFN)-induced depression and review the use of antidepressants for treatment of depressive symptoms associated with IFN therapy.CASE SUMMARY: A 43-year-old white woman with chronic hepatitis C and severe IFN-induced depression was treated with sustained-release bupropion initiated at 150 mg/day for 7 days and 100 mg twice daily thereafter. The dosage was increased again, to 350 mg/day when depressive symptoms recurred. While receiving that dose and continuing IFN treatment, she reported significant improvement in her depressive symptoms without experiencing any adverse effects.DISCUSSION: There is limited evidence suggesting that IFNs decrease central serotonergic transmission. There are several published reports on the use of selective serotonin-reuptake inhibitors for the treatment of IFN-induced depression. However, controlled studies are needed to assess the efficacy of serotonergic and noradrenergic antidepressants in IFN-treated patients with depressive symptoms.CONCLUSIONS: Sustained-release bupropion might be of potential benefit in patients with interferon-induced depression. |
| Databáze: |
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