Prenatal diagnosis of a giant congenital primary cerebral hemangiopericytoma

Autor: Sobel, Gabor, Halász, Judit, Bogdányi, Katalin, Szabó, István, Borka, Katalin, Molnár, Péter, Schaff, Zsuzsa, Paulin, Ferenc, Bánhidy, Ferenc
Zdroj: Pathology & Oncology Research; March 2006, Vol. 12 Issue: 1 p46-49, 4p
Abstrakt: Abstract: Congenital primary intracraniai hemangiopericytomas are exceptionally rare tumors. We present a case of a fetus, with the prenatal sonogram at 33 weeks of gestation revealing a large cerebral tumor. Because of the enlarged head, a cesarean section was performed. The tumor was confirmed by postnatal ultrasound, magnetic resonance imaging (MRI) and biopsy. Elevated intracraniai pressure and hemorrhage led to death on the 11th day. Autopsy revealed a 10×9 cm large inhomogeneous tumor located centrally, mainly in the posterior fossa. Histology showed a hypercellular and hypervascular tumor with extended necrosis and high mitotic rate. The tumor cells were positive for vimentin and CD34 antigens and negative for several neurological markers, desmin and CD31. The diagnosis of a congenital primary cerebral hemangiopericytoma was confirmed.
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