| Autor: |
Naredo, Esperanza, Rodríguez, Manuel, Campos, Cristina, Rodríguezheredia, José Manuel, Medina, Julio A., Giner, Emilio, Martínez, Olga, Toyos, Francisco Javier, Ruíz, Teresa, Ros, Inmaculada, Pujol, Manuel, Miquel, Xavier, García, Luz, Aznar, Juan José, Chamizo, Eugenio, Páez, Manuel, Morales, Pilar, Rueda, Amalia, Tuneu, Roser, Corominas, Hector, de Agustín, Juan José, Moragues, Carmen, Mínguez, Dolores, Willisch, Alfredo, Gonzálezcruz, Isabel, Aragón, Angel, Iglesias, Gerardo, Armas, Carlos, Pablo valdazo, Juan, Vargas, Carmen, Calvoalén, Jaime, Juanmas, Antonio, Salvador, Georgina, Puigdollers, Angels, Galíndez, Eva, Garrido, Noemi, Salaberri, José, Raya, Enrique, Salles, Meritxell, Díaz, César, Cuadra, José luis, Garrido, Jesús |
| Zdroj: |
Arthritis Care and Research; April 2008, Vol. 59 Issue: 4 p515-522, 8p |
| Abstrakt: |
ObjectiveTo investigate the validity, reproducibility, and responsiveness of a simplified power Doppler ultrasound PDUS assessment of joint inflammation compared with a comprehensive 44joint PDUS assessment in patients with rheumatoid arthritis RA who started therapy with a biologic agent.MethodsA total of 160 patients with active RA who started a biologic agent were prospectively recruited in 18 Spanish centers. The patients underwent clinical and laboratory assessment and blinded PDUS examination at baseline and 6 months. A PDUS examination of 128 synovial sites in 44 joints was performed. US synovitis and PD signal were semiquantitatively graded from 1 to 3 in all synovial sites. US count and index for synovitis and PD signal were obtained. PDUS intraobserver and interobserver reliability were evaluated. A process of data reduction based on the frequency of involvement of synovial sites by both synovitis and PD signal was conducted. Construct and discriminant validity of a simplified PDUS assessment was investigated.ResultsA PDUS simplified assessment including 24 synovial sites from 12 joints detected 100 of patients with synovitis and 91 of patients with PD signal. There was a highly significant correlation between the 44joint count and index for synovitis and PD signal and the 12joint count and index for synovitis and PD signal at baseline and 6 months r 0.84–0.90, P< 0.0005. The smallest detectable difference was lower than the mean change in simplified PDUS variables.ConclusionA 12joint PDUS assessment of RA joint inflammation may be a valid, feasible method for multicenter monitoring of therapeutic response to biologic agents. |
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