| Autor: |
Bastounis, Elias, Hadjinikolaou, Leonidas, Pikoulis, Manolis, Tsigris, Christos, Marinos, Evangelos, Toutouzas, Paulos |
| Zdroj: |
Cardiovascular Research; December 1994, Vol. 28 Issue: 12 p1868-1868, 1p |
| Abstrakt: |
Objective: The aim was to define the following: (1) if reperfusion of ischaemic limbs could cause myocardial damage; (2) if reactive oxygen metabolites are involved in such possible damage. Methods: Ten rats underwent ischaemia-reperfusion of the lower limbs (group A) and 10 underwent the same procedure following treatment with ascorbic acid (group B). Ten rats were used as a control group (group C). Results: The incidence of severe myocardial mitochondrial damage and serum malondialdehyde concentrations 30 min after reperfusion were both higher in group A than in groups B and C [8/10, 2/10, and 0/10, p < 0.05 and 7.25(SEM 0.33), 5.30(0.26), and 4.89(0.23) µmol.litre–1, p < 0.05, respectively]. Conclusions: Ischaemia-reperfusion of the lower limbs may cause mitochondrial damage in the myocardium and reactive oxygen metabolites could mediate this damage. Cardiovascular Research 1994;28: 1868-1871 |
| Databáze: |
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