| Autor: |
T. Murphy, Brian, Brodie, Peggie, Slebodnick, Carla, S. Miller, James, Birkinshaw, Chris, M. Randrianjanaka, Lucien, Andriantsiferana, Rabodo, E. Rasamison, Vincent, TenDyke, Karen, M. Suh, Edward, G. I. Kingston, David |
| Zdroj: |
Journal of Natural Products; February 2008, Vol. 71 Issue: 3 p325-329, 5p |
| Abstrakt: |
Bioassay-guided fractionation of an ethanol extract of a Malleastrumsp. afforded three new limonoids, malleastrones A−C ( 1− 3), respectively. Each limonoid contained a rare tetranortriterpenoid skeleton. Structure elucidation of the isolates was carried out by analysis of one- and two-dimensional NMR and X-ray diffraction data. The novel isolates 1and 2were tested for antiproliferative activity against a panel of cancer cell lines and exhibited IC 50values ranging from 0.19 to 0.63 µM. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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