| Autor: |
Harding, Paul, Surveyor, Gulnar, Brigstock, David |
| Zdroj: |
Mitochondrial DNA: The Journal of DNA Mapping, Sequencing, and Analysis; 1998, Vol. 8 Issue: 6 p385-390, 6p |
| Abstrakt: |
Connective tissue growth factor (CTGF) is a 38kDa mitogen and chemotactic factor for fibroblasts that is transcriptionally activated by serum or transforming growth factor-β and may play a role in wound healing and various skin diseases. In these studies, pig endometrium was shown to contain a single CTGF transcript of 2.4kb and to produce a 38kDa CTGF-immunoreactive protein. Cloning and sequencing of a 1.5kb pig uterine CTGF cDNA revealed that the predicted pCTGF primary translation product displayed 92% identity to human CTGF and 93% identity to mouse CTGF. The pCTGF cDNA encoded a 26 amino acid signal peptide followed by a 323-residue sequence containing 38 highly conserved cysteine residues. In common with mouse and human CTGF proteins, pCTGF is predicted to resemble a multi-functional mosaic protein that contains four distinct modules. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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