Review Cardiovascular & Renal; Recent Developments in Glycoprotein llb/llla Antagonists

Autor: Raddatz, Peter, Gante, Joachim
Zdroj: Expert Opinion on Therapeutic Patents; November 1995, Vol. 5 Issue: 11 p1165-1183, 19p
Abstrakt: Platelet adhesion and aggregation, which have been identified as promising targets for the development of antithrombotic drugs, are mediated by a family of glycoprotein receptors. Antagonists of the most important of these receptors, Gpllb/llla, are currently under investigation for a range of both cardiovascular and cerebrovascular disorders. This article aims to compare data for existing Gpllb/llla antagonists in various stages of clinical development, with those compounds which appear in the recent patent literature.
Databáze: Supplemental Index