| Autor: |
Hou, Yanpeng, Cao, Shugeng, Brodie, Peggy, S. Miller, James, Birkinshaw, Chris, Ratovoson, Fidisoa, Rakotondrajaona, Roland, Andriantsiferana, Rabodo, E. Rasamison, Vincent, G. I. Kingston, David |
| Zdroj: |
Journal of Natural Products; January 2008, Vol. 71 Issue: 1 p150-152, 3p |
| Abstrakt: |
Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensisssp. madagascariensisled to the isolation of the four new cassane diterpenoids 1− 4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1and 2showed mild antiproliferative activity with IC 50values of 10 and 36 µM, respectively. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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