| Autor: |
Cornetta, Tommaso, Padua, Luca, Testa, Antonella, Ievoli, Elena, Festa, Fabiola, Tranfo, Giovanna, Baccelliere, Luigi, Cozzi, Renata |
| Zdroj: |
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis; February 2008, Vol. 638 Issue: 1-2 p75-82, 8p |
| Abstrakt: |
Many antineoplastic drugs have been found to have carcinogenic, mutagenic and teratogenic activity and so hospital personnel handling these substances are potentially exposed to health risk. Understanding this risk derived from protracted occupational exposure has great relevance even if the workers normally adopt individual and environmental protective measures. To address this question we have studied the presence of DNA and chromosome damage in a population of nurses employed in Italian oncology units and in matched controls. We used the comet assay to evidence the presence of DNA strand breaks, due to both acute and chronic exposure, and the micronucleus (MN) test, which is a measure of clastogenic and aneugenic events. Furthermore, since the individual response to the exogenous insults may be genetically determined, we studied the possible influence of single nucleotide polymorphism in XRCC1 and XRCC3 DNA repair genes on induced genetic damage. We also considered the effects of confounding factors like smoking, age and gender. |
| Databáze: |
Supplemental Index |
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