| Autor: |
Karkare, Sampada, Adou, Eba, Cao, Shugeng, Brodie, Peggy, S. Miller, James, M. Andrianjafy, N., Razafitsalama, J., Andriantsiferana, Rabodo, E. Rasamison, Vincent, G. I. Kingston, David |
| Zdroj: |
Journal of Natural Products; November 2007, Vol. 70 Issue: 11 p1766-1770, 5p |
| Abstrakt: |
Bioassay-guided fractionation of an ethanol extract of Roupellina (Strophanthus) boiviniifrom the rainforest of Madagascar afforded the six new cardenolide glycosides boivinides 1– 6, as well as the four known cardenolide glycosides digitoxigenin 3- O-[β- d-glucopyrananosyl-(1→4)-α- l-acofriopyranoside], corotoxigenin 3- O-β- d-boivinoside, 17α-corotoxigenin 3- O-β- d-sarmentoside, and uzarigenin 3- O-α- l-rhamnoside. The structures of these compounds were elucidated by various 1D and 2D NMR techniques. All new compounds showed significant antiproliferative activity against the A2780 human ovarian cancer cell line, with boivinide A being the most active at IC 50= 0.17 µM. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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