| Autor: |
Smolensky, M. H., D'alonzo, G. E., Kunkel, G., Barnes, P. J. |
| Zdroj: |
Chronobiology International; 1987, Vol. 4 Issue: 3 p459-466, 8p |
| Abstrakt: |
Many asthmatic patients experience aggravation of symptoms overnight resulting in disruption of their sleep. Sustained-release theophylline represents at this time a major bronchodilator medication which possesses a sufficient duration of activity to avert the nocturnal breathing distress of asthma. Circadian rhythm-adapted theophylline schedules consisting of unequal dosing——more or all the drug taken in the evening——have proven efficacious in clinical investigations for certain patients. Although the kinetic behavior of some formulations is affected by food, the circadian rhythm-adapted schedules represent a significant step forward toward the goal of optimizating sustained-release theophyllines for patients who experience nighttime symptoms. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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