| Autor: |
Erkiliç, Asli Baykal, Isbir, Mehmet, Özdem, Sadi, Ögütman, Clagklar |
| Zdroj: |
Clinical and Experimental Hypertension; 1996, Vol. 18 Issue: 1 p77-86, 10p |
| Abstrakt: |
Cellular abnormalities associated with elevated Can+ concentrations have been postulated to be involved in the pathogenesis of hypertension. The present study was undertaken to investigate the effects of blood pressure changes on cytosolic Ca2+ levels in erythrocytes. Cadmium, which has been implicated in the etiology of hypertension was used as the hypertensive agent and the classical blocker of voltage-operated calcium channels nifedipine was used to treat hypertension. 10 weeks old male rats were divided into four groups; control, CdCl2, CdCl2 and nifedipine, nifedipine groups. CdC12 caused elevations in blood pressure and in the cytosolic erythrocyte Ca2+ levels both of which were reduced after nifedipine administration. After nifedipine alone, cytosolic Ca2+ levels were increased. These findings suggest that cytosolic Ca2+ content decreasing action of nifedipine in the CdC12 and nifedipine applied group could be secondary to the antihypertensive. |
| Databáze: |
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