| Abstrakt: |
Histamine in the brain is located in at least two cell types: neurons and mast cells. Neuronal histamine is found in the synaptosomal fraction, has a rapid turn-over rate and is accepted to play a neurotransmitter role. Experimental evidence exists that histamine, is active in the central regulation of blood pressure, arousal, drinking behaviour, mood, reaction to stress and thermoregulation. Mast cell histamine is storedin vesicles and has a slow turnover rate. Its function in the CNS remains obscure(For a review see: Schwartz 1975; Gross, 1982). Stressful situations (platform, airblast, restraint…) are reported to increase or decrease cerebral histamine turnover rate with or without changing endogenous histamine levels (Mazurkiewicz-Kwilecki & Bielkiewicz, 1982). |
