| Autor: |
Nonaka, Yasuko, Ohtaki, Hirokazu, Ohtsuka, Etsuko, Kocha, Tomoji, Fukuda, Teruo, Takeuchi, Tomio, Aoyagi, Takaaki |
| Zdroj: |
Journal of Enzyme Inhibition; 1995, Vol. 10 Issue: 1 p57-63, 7p |
| Abstrakt: |
Ebelactones A and B, natural products from Streptomyces aburaviensis are potent inhibitors of pancreatic lipase. Lipase is the key enzyme required for the absorption of dietary triglycerides (TG). Ebelactone B inhibited, in a dose-dependent manner, the intestinal absorption of fat after fat-feeding in the rat. The most effective inhibition was observed when the inhibitor was administered at 60 min prior to fat-feeding. When ebelactone B (10 mg/kg) was administered, the serum levels of TG (58%) and cholesterol (36%) were decreased. Since ebelactone B effectively inhibits absorption of dietary fat, it may provide a promising means for prophylaxis or therapeutics of hyperlipidemia and obesity. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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