| Autor: |
Carey, Robert, Hilgenberg, Alan, Wilkins, E. W., Choi, N. C., Mathisen, Douglas, Grillo, Hermes, Wain, John, Logan, Diana, Bromberg, Cheryl |
| Zdroj: |
Cancer Investigation; 1993, Vol. 11 Issue: 2 p99-105, 7p |
| Abstrakt: |
Seventy patients with local squamous cell carcinoma of the esophagus were treated between 1981 and 1990 with preoperative chemotherapy, surgical resection, and possible postoperative radiation therapy and/or chemotherapy. Chemotherapy included two cycles of 5-fluorouracil (1000 mg/m2) by continuous intravenous infusion on days 1-4 and cisplatin (100 mg/m2) on day 4. Complete clinical response (CCR) was achieved in 28 (41%) patients, partial clinical response (PCR) in 17 (25%), and no response in 23 (34%).Fifty-five (81%) patients were resected, 6 (9%) were explored, and 7 (10%) were unable to have surgery.Microscopic analysis of 55 resected patients showed 50 (91%) with active tumor, 1 (2%) with necrotic tumor, and 4 (7%) with a pathological complete response to chemotherapy.Twenty-six of the 55 resected patients (47%) had no gross evidence of disease at the time of surgical inspection. Median overall survival was 21.86 months (range 2-107 months) for all patients and 26.71 months (range 2-107 months) for resected patients. Actuarial S-year survival rate was 31% for all patients and 39% for resected patients. Prolonged survival correlates with complete clinical response to chemotherapy, low pathological stage of disease, and successful resection of the lesion. |
| Databáze: |
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