| Autor: |
Beck, L. Steven, Chen, Theresa, Mikalauski, Philip, Ammann, Arthur |
| Zdroj: |
Growth Factors; 1990, Vol. 3 Issue: 4 p267-275, 9p |
| Abstrakt: |
A new animal model to study secondary intention wound healing and the effects of topically applied rhTGF-β1 was developed. A time course study was performed of full thickness 6 mm punch wounds placed on the backs of anesthetized pigs and treated once with either 3% methylcellulose or rhTGF-β1 in 3% methylcellulose or left untreated. Wounds receiving rhTGF-β1 had enhanced tensile strength at days 4 and 7 compared to controls. Studies of the response on days 4 and 7 to graded doses of rhtGF-β1 showed that a dose of 250 or 2500 ng rhTGF-β1 gave a similar enhanced wound strength, while 25 ng rhTGF-β1 had no effect. Blood flow to treated granulating wounds as measured by 141Ce microspherrs indicate an increase in flow in wounds treated with 250, 500 or 2500ng rhTGF-β1 compared to controls. These results indicate a possible use for rhTGF-β1 in enhancing wound healing clinically. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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